منابع مشابه
Saliva carbamazepine and phenytoin level monitoring.
Saliva carbamazepine and phenytoin samples were used to monitor treatment in 35 children aged between 2 and 14 years during a 2-year period. All phenytoin levels and over half the carbamazepine levels that were above the therapeutic range were associated with adverse effects. Dose and carbamazepine saliva levels were significantly related but no such relationship was found for phenytoin. There ...
متن کاملCan a single measurement of carbamazepine suffice for therapeutic monitoring?
Using fluorescence polarization immunoassay, we measured the peak and trough concentrations of total and free carbamazepine in serum and saliva from 33 epileptic children. We found that, except for patients who show side effects, measurement of trough values in a single sample, collected after an overnight fast and before the morning dose, sufficiently estimates clinical response. Moreover, tot...
متن کاملHematological monitoring during therapy with carbamazepine in children.
Carbamazepine (CBZ) is being prescribed more frequently for treatment of children and adults with generalized tonicclonic and partial complex seizures. Early reports of aplastic anemia in elderly patients treated with this drug led to concern about its potential hematological toxicity. A variety of other hematological abnormalities have also been described in association with CBZ therapy, inclu...
متن کاملMarkedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxid...
متن کاملNon-Recurrence of Carbamazepine Induced Vitiligo after Rechallenge with Carbamazepine
OBJECTIVE Vitiligo is a rare side effect of carbamazepine whose exact mechanism is unknown. The aim of this report is to describe a single case of vitiligo induced by carbamazepine. METHODS The case was a patient with Bipolar I disorder whose medications were changed from valproate to carbamazepine and who developed vitiligo after a short while. We followed the case for about four years when ...
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ژورنال
عنوان ژورنال: Psychiatric Bulletin
سال: 1993
ISSN: 0955-6036,1472-1473
DOI: 10.1192/pb.17.12.718